E-cigarettes are considered a less harmful alternative to classical tobacco cigarettes. The impact of E-cigarettes on cardiovascular health remains elusive. E-cigarette aerosol can lead to the alteration of inflammatory and oxidative stress pathways, ultimately resulting in vascular endothelial dysfunction, thrombogenesis, and atherosclerosis [1].
A recent All of Us Research Program sponsored by the NIH carried out a prospective analysis of participants and their electronic health to determine the association between the use of electronic nicotine products and the incidence of heart failure. The use of electronic cigarettes can independently increase the risk of heart failure and heart failure with preserved ejection fraction (see Graphic) [2].
References: 1. Kuntic M, Hahad O, Daiber A, Muenzel T. Could E-cigarette vaping contribute to heart disease?. Expert review of respiratory medicine. 2020.14(11):1131-39. 2. Bene-alhasan Y, Mensah SO, Almaadawy O, Dwumah-Agyen M, Pingili A, Mlilo M, Osei AD. Electronic nicotine product use is associated with incident heart failure-The all of us research program. Journal of the American College of Cardiology. 2024.83(13):695.