Consumption of coffee has been documented to prevent the development of colorectal cancer (CRC) or improve prognosis after the diagnosis of CRC. Coffee is known to have chemopreventive properties. The possible mechanisms by which coffee consumption can influence colorectal carcinogenesis are attributed to the anti-inflammatory, antioxidant, antiproliferative, pro-apoptotic, and insulin-sensitizing properties of the heterogeneous components of coffee.
A study conducted by Oyelere AM et al., recently published in the “International Journal of Cancer”, reported that coffee consumption is associated with a lower risk of CRC recurrence and all-cause mortality in patients with Stage I–III CRC. The association between coffee consumption and all-cause mortality was noted at an optimal intake of 3–5 cups/day and the lowest risk at 4 cups/day (see the Graphic for the study snapshot).
Source: Oyelere AM, Kok DE, Bos D, Gunter MJ, Ferrari P, Keski-Rahkonen P, de Wilt JHW, van Halteren HK, Kouwenhoven EA, van Duijnhoven FJB, Kampman E. Coffee consumption is associated with a reduced risk of colorectal cancer recurrence and all-cause mortality. Int J Cancer. 2024 Feb 12. Doi: 10.1002/ijc.34879